Topics: Transcriptomics (Illumina)
Origin: Academic
Project type: Service
Name of Applicant: Eric Camerer
Date of application: 18-10-2019
Unit: Other
Location: 56 rue Leblanc, Paris 75015
Phone: 0153988048
@ Mail: eric.camerer@inserm.fr
Project context and summary: Protease-activated receptors are G protein-coupled receptors that mediate biological responses to extracellular serine proteases. They play important roles in hemostasis and contribute to cancer and inflammation when deregulated. In order to identify new roles for PARs and to define critical signaling pathways downstream of this receptor family, we have generated global and conditional knockouts of PARs as well as the biological inhibitors of their principal protease agonists. Loss and gain of PAR function both result in embryonic lethality. This project aims to identify important effector pathways downstream of PAR signaling.
Related team publications:Camerer E, Barker A, Duong DN, Ganesan R, Kataoka H, Cornelissen I, Darragh MR, Hussain A, Zheng YW, Srnivasan Y, Farady CJ, Brown C, Xu SM, Lin CY, Craik CS, Kirhhofer D and Coughlin SR. Local protease signalling contributes to neural tube closure in the mouse embryo. Dev Cell 2010; 18:25-38
Le Gall SM, Szabo R, Lee, M, Kirhhofer D, Craik CS, Bugge TH, and Camerer E. Matriptase activation connects tissue factor-dependent coagulation initiation to epithelial proteolysis and signaling. Blood, 2016;127: 3260–3269.
Szabo R, Peters DE, Kosa P, Camerer E and Bugge TH. Regulation of feto-maternal barrier by matriptase- and PAR-2-mediated signaling is required for placental morphogenesis and mouse embryonic survival. PLoS Genet 2014;10:e1004470.
Manager: marc.monot@pasteur.frStatus: Closed
