Topics: Origin: Project type: Development
Name of Applicant: Julian Garneau
Date of application: 14-04-2026
Unit: Academic
Location: Phone: 0782552723
@ Mail: julian.garneau@unil.ch
@ PI-Mail: pascale.vonaesch@unil.ch
Project context and summary: Non-communicable diseases (NCDs), including obesity, diabetes, and cardiovascular disorders, are major global health challenges. Increasing evidence highlights early-life nutrition and the gut microbiota as critical determinants of lifelong health. Malnutrition during this critical developmental window, whether undernutrition or overnutrition, is known to alter gut microbial community assembly and structure. However, how bacterial strains adapt to malnutrition and how these adaptations influence long-term host susceptibility to disease remain poorly understood.
Related team publications:Vonaesch, P., Araújo, J. R., Gody, J. C., Mbecko, J. R., Sanke, H., Andrianonimiadana, L., Naharimanananirina, T., Ningatoloum, S. N., Vondo, S. S., Gondje, P. B., Rodriguez-Pozo, A., Rakotondrainipiana, M., Kandou, K. J. E., Nestoret, A., Kapel, N., Djorie, S. G., Finlay, B. B., Wegener Parfrey, L., Collard, J. M., Randremanana, R. V., … Afribiota Investigators (2022). Stunted children display ectopic small intestinal colonization by oral bacteria, which cause lipid malabsorption in experimental models. Proceedings of the National Academy of Sciences of the United States of America, 119(41), e2209589119. https://doi.org/10.1073/pnas.2209589119
Collard, J. M., Andrianonimiadana, L., Habib, A., Rakotondrainipiana, M., Andriantsalama, P., Randriamparany, R., Rabenandrasana, M. A. N., Weill, F. X., Sauvonnet, N., Randremanana, R. V., Guillemot, V., Vonaesch, P., Sansonetti, P. J., & Afribiota Investigators (2022). High prevalence of small intestine bacteria overgrowth and asymptomatic carriage of enteric pathogens in stunted children in Antananarivo, Madagascar. PLoS neglected tropical diseases, 16(5), e0009849. https://doi.org/10.1371/journal.pntd.0009849
Status: New
