The outer membrane (OM) is a defining feature of diderm bacteria. It is composed of an asymmetric bilayer, with an inner leaflet of glycerophospholipids and an outer leaflet of lipopolysaccharides (LPS), as well as outer membrane proteins (OMPs). Outer membrane biogenesis has been mainly studied in Escherichia coli; however, our understanding of this process in other model bacteria remains limited, particularly in species belonging to the Terrabacteria clade, as opposed to the Gracilicutes, which include E. coli.
The aim of this project is to understand how OM biogenesis is regulated in a new diderm bacterial model, Veillonella parvula, a member of the Terrabacteria.
