The immune system is built in successive waves that differ in cellular origin and fate, including two major embryonic waves of unclear function, temporal impact, and medical relevance. We aim to elucidate how prenatal perturbations such as maternal inflammation affect embryonic progenitors and their long-lived progeny, the tissue resident macrophages. We will characterize the long-lasting consequences of prenatal inflammation on hematopoietic stem cell homeostasis and on macrophage functions during tissue repair.
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