Topics: Genomics (Long Read)
Origin: IP
Project type: Expertise
Name of Applicant: Liliana Mancio
Date of application: 04-04-2025
Unit: Biology of Host-parasite Interactions
Location: Sergent 03 06
Phone: 0637978850
@ Mail: liliana.mancio@pasteur.fr
Project context and summary: Malaria-causing Plasmodium parasites can linger in the human liver for weeks to years in a dormant state and reactivate to cause recurring infections. These dormant parasites are a key target for malaria eradication efforts. The goal of this project is to understand and unravel the molecular mechanisms underlying dormancy, as well as the transmission of parasites to mosquitoes. Additionally, the project aims to lay the groundwork for the future development of new therapies targeting liver infection reservoirs.
Related team publications:A single-cell liver atlas of Plasmodium vivax infection. Mancio-Silva L, Gural N, Real E, Wadsworth MH 2nd, Butty VL, March S, Nerurkar N, Hughes TK, Roobsoong W, Fleming HE, Whittaker CA, Levine SS, Sattabongkot J, Shalek AK, Bhatia SN. Cell Host Microbe. 2022 Jul 13;30(7):1048-1060.e5. doi: 10.1016/j.chom.2022.03.034. Epub 2022 Apr 19. PMID: 35443155
In Vitro Culture, Drug Sensitivity, and Transcriptome of Plasmodium Vivax Hypnozoites. Gural N, Mancio-Silva L, Miller AB, Galstian A, Butty VL, Levine SS, Patrapuvich R, Desai SP, Mikolajczak SA, Kappe SHI, Fleming HE, March S, Sattabongkot J, Bhatia SN. Cell Host Microbe. 2018 Mar 14;23(3):395-406.e4. doi: 10.1016/j.chom.2018.01.002. Epub 2018 Feb 22. PMID: 29478773
Manager: chloe.baum@pasteur.frStatus: Kick-off meeting
