Project

Pandemic IAVs emerge as a consequence of the segmentation of IAVs genome into a bundle of eight distinct vRNAs, through mixing (termed reassortment), in progeny viruses, of genome segments from animal or human co-infecting IAVs. We recently developed a technology for large-scale single virion sequencing (µFlu), which we will leverage to (i) better understand how host-pathogen interactions can shape reassortment and comprehensively analyse the relative fitness of reassortants, (ii) monitor the zoonotic/pandemic potential of circulating IAVs and (iii) characterize the evolution and dynamics of IAV genotypes in severely immunocompromised patients with prolonged IAV shedding.