Canine distemper virus (CDV) poses a significant threat to the endangered Ethiopian wolf (EW) population as well as domestic dogs (DD) residing in and around Bale Mountains National Park (BMNP) in Ethiopia. Although previous studies suggest this fact, the epidemiology and characterization of the virus have been poorly studied. This study aims to investigate the molecular epidemiology and genomic characterization of CDV in these vulnerable populations. The study will employ a multidisciplinary approach, combining field surveys, sample collection, molecular techniques, and bioinformatics analysis to achieve its objectives. The first phase of the research will involve a comprehensive survey of CDV prevalence and distribution among EW and DD in the study area. Subsequently, a molecular characterization of CDV strains will be carried out using advanced sequencing technologies. This will allow for a detailed analysis of the viral genome, including the identification of genetic variations, mutations, and potential viral adaptations. Comparative genomic analysis will be conducted to determine whether distinct CDV lineages exist between EW and DD, and the genome of circulating CDV strains in the EW and DD with that of the CDV vaccine strains currently available in the country. Furthermore, the study aims to elucidate the transmission dynamics of CDV between EW and DD. By analyzing the genetic relatedness of CDV strains, combined with spatial and temporal data, the research will shed light on the routes and mechanisms of viral transmission within and between these populations. The findings of this study will contribute to a better understanding of CDV epidemiology, genetic diversity, and transmission dynamics in the endangered EW population and DD residing in and around BMNP. This knowledge will be crucial in developing effective strategies for the the prevention, control, and management of CDV in these vulnerable populations, ultimately aiding in the conservation of EW.
Related team publications: