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#18517 : High throughput dissection of the developmental control of African trypanosome infectivity in the Tsetse Fly by coupling inducible RNAi library screens with single-cell RNA-seq
Topics: Genomics (Illumina)
Origin: IP
Project type: Expertise

Name of Applicant: Karinna Rubio Pena
Date of application: 15-07-2024
Unit: Trypanosomes Molecular Biology
Location: Metchnikoff (67) – 2eme – 2012-13
Phone: 0144389422
@ Mail: karinna.rubio@pasteur.fr
@ PI-Mail: lucy.glover@pasteur.fr

Project context and summary:

Trypanosoma (T) brucei is a protozoan parasite that is transmitted by the tsetse fly and causes the debilitating and often fatal neglected tropical disease human African trypanosomiasis (HAT, also known as sleeping sickness) or animal African trypanosomiasis. As trypanosomes progress from the mammalian host through the tsetse fly insect vector, they encounter varied environments, which require specific life cycle changes to survive in these divergent niches. Trypanosome cellular plasticity underpins their ability to traverse these diverse environments, with at least 9 life cycle steps in both hosts. we aim to understand trypanosome developmental progression in the tsetse fly, how individual cells differentiate as they move between different tissue types and which gene regulatory networks govern these processes.


Related team publications:
Service Delivery
Manager: azimdine.habib@pasteur.fr
Status: Quotation sent


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