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#18437 : Recherche d’agents pathogènes viraux dans les populations de Garimpeiros en Guyane
Topics: Metagenomics (Shotgun)
Origin: RIIP
Project type: Expertise

Name of Applicant: Anne Lavergne
Date of application: 28-06-2024
Unit: Other
Location: IPG French Guiana
Phone: +594694295801
@ Mail: anne.lavergne@pasteur.fr

Project context and summary:

The Amazonian region meets favorable factors for the occurrence of viral epidemics and the emergence of new pathogens due to its high diversity of vectors and hosts, environmental perturbation, growing urbanization and increased contact between animals/vectors and human population. French Guiana is no exception to this rule, with regularly reported cases of diseases for which viral etiological agents (such as Mayaro, Oropouche or the yellow fever virus) are mainly of sylvatic origin with reservoirs such as primates, birds or rodents.
In French Guiana, some populations, such as the garimpeiros that are involved in illegal gold mining, are particularly exposed to these forest arboviruses. This precarious population remains far removed from the healthcare system. These migrants from Brazil live on remote sites, sometimes three or four days’ walk or by boat into the forest.
As part of the CUREMA project, which aims to assess the effectiveness and feasibility of a strategy to combat malaria in garimpeiros populations, the search for viral pathogens in a sub-population of symptomatic patients was initiated.
The objective of this study is to carry out an inventory of etiological viral agents that can be responsible of fever within garimperos population living in Forest. The secondary objective is to take advantage of this research to find new agents at risk of emergence.
In this project, 50 patients were included for whom classical diagnostic did not identify etiological agents (malaria, dengue, chikungunya, Mayaro, Oropouche etc…)
This will allow improving knowledge on viral agents circulating in rainforest in French Guiana and developing or adapting new diagnostic tools.


Related team publications:
Etiology of Acute Febrile Illnesses in Adults in the Defense Community in French Guiana. Velut G, de Laval F, Berry M, Dufour Gaume F, André N, Epelboin L, Lavergne A, Enfissi A, Djossou F, Rousset D, Briolant S. Am J Trop Med Hyg. 2024 Feb 20;110(4):819-825. doi: 10.4269/ajtmh.22-0638. Print 2024 Apr 3. PMID: 38377600.
– Review on Main Arboviruses Circulating on French Guiana, An Ultra-Peripheric European Region in South America. Bonifay T, Le Turnier P, Epelboin Y, Carvalho L, De Thoisy B, Djossou F, Duchemin JB, Dussart P, Enfissi A, Lavergne A, Mutricy R, Nacher M, Rabier S, Talaga S, Talarmin A, Rousset D, Epelboin L. Viruses. 2023 May 29;15(6):1268. doi: 10.3390/v15061268. PMID: 37376570
The Influence of Habitat on Viral Diversity in Neotropical Rodent Hosts. Tirera S, de Thoisy B, Donato D, Bouchier C, Lacoste V, Franc A, Lavergne A. Viruses. 2021 Aug 26;13(9):1690. doi: 10.3390/v13091690. PMID: 34578272
Service Delivery
Manager: azimdine.habib@pasteur.fr
Status: Closed


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