The presence and fate of tumor-infiltrating immune cells, which exert pressure on tumor cells and have prognostic value, can be altered by the inflammatory microenvironment. While the innate immune response is the first line of defense against pathogens, it can also induce disorders and chronic pathologies and correlate with tumor development, which can be facilitated by aberrant immune responses or environmental factors. Innate lymphoid cells are tissue-resident lymphocytes that promote mucosal homeostasis and immunity. In contrast, the surveillance behavior of ILCs in intestinal tumorigenesis is largely unknown. Here, we investigate the role of intestinal ILCs in tumor progression. Using a single cell RNAseq approach, we plan to perform a transcriptional profiling analysis of tumor-infiltrating ILCs.
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