We would like to assess how the deficiency of the Ets1 transcription factor impacts on the developmental trajectory of B cells in the bone morrow at the single B-cell level. For this, we will use chimeric animals reconstituted either with Est1-/- or Est1+/+ fetal liver hematopoietic precursors and analyse by single cell multiomics (ATAC + GEX) the different subsets of developing B cells isolated from the bone marrow of these animals.
Related team publications: