Topics: Single Cells (GEX/ATAC/ADT/Multiome…)
Origin: IP
Project type: Service
Name of Applicant: Hervé Tostivint
Date of application: 14-11-2023
Unit: Other
Location: 7, rue Cuvier, 75005 Paris
Phone: 0140793619
@ Mail: herve.tostivint@mnhn.fr
Project context and summary: Urotensin 2(Uts2) is a neuropeptide initially in fish in the basis of its vasoactive properties. Subsequent studies have demonstrated its existence in all vertebrate species.
In fish, such as zebrafish, the uts2 gene is mainly expressed in neurosecretory neurons located in the spinal cord called Dahlgren cells, while in tetrapods, it is known to be primarily expressed in motoneurons. However, in the xenopus tadpole, we found that uts2-expressing cells are not motoneurons.
The goal of our project is to gain more insights into these cells, still of unknown nature. For this purpose, we will carry out the transcriptome of uts2-expressing cells in xenopus at various developmental stages in order to compare it with that of zebrafish.
Related team publications:Tostivint H., Girardot F., Parmentier C., Pézeron G. (2022) Le système neurosécréteur caudal, l’autre système « neurohypophysaire » des poissons. Biologie aujourd’hui 216:89-103.
Gaillard A.L., Mohamad T., Quan F.B., de Cian A., Mosimann, C., Tostivint H., Pézeron G. (2023) Urp1 and Urp2 act redundantly through utsr3 to maintain spine shape in zebrafish larvae. Developmental Biology, 496:36-51.
Alejevski F., Leemans M., Gaillard A.L., Leistenschneider D, de Flori C., Bougerol M., Le Mével S., Herrel A., Fini J.B., Pézeron G., Tostivint H. (2021) Conserved role of the urotensin 2 receptor 4 signaling pathway to control spine straightness in a tetrapod. Open Biology 11: 210065.
Manager: marc.monot@pasteur.frStatus: Closed
