Status: Pending
Pathogen leptospires are responsible for the zoonotic disease leptospirosis. The clinical manifestations of this infection range from a febrile state to a severe life-threatening form characterized by multiple organ hemorrhages. More than one million cases of leptospirosis are currently reported annually in the word, with 10% of mortality. Leptospira are extracellular pathogens that penetrate hosts and rapidly disseminate to target organs (including kidney, liver, lungs) throughout the bloodstream. During infection, Leptospira are confronted with deadly oxidants, including superoxide radical. We have isolated a L. interrogans strain that has acquired a steady resistance to superoxide. Our aim is to identify any epigenetic mechanisms underlying the resistance to superoxide.
Submitted: 2023-08-22 14:46 · Last updated: 2023-08-22 14:46