Project

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#7298 : Phage adaptation to CRISPR immunity
Topics: Genomics (PacBio/Long Read)
Origin: Academic
Project type: Expertise

Name of Applicant: martin Guillemet
Date of application: 09-06-2022
Unit: Other
Location: Montpellier
Phone: 0678893109
@ Mail: martin.guillemet@cefe.cnrs.fr
@ PI-Mail: sylvain.gandon@cefe.cnrs.fr

Project context and summary:

We aim to study the adaptation of virulent phages in a heterogeneous population of CRISPR resistant bacteria. We will carry out an evolution experiment and we will sequence evolved phages through time to track the spread of escape mutations in the phage genome. Pacbio HiFi sequencing will allow us to follow the dynamics of multilocus phage genotypes.


Related team publications:
https://www.biorxiv.org/content/10.1101/2021.11.12.468349v2
Service Delivery
Manager: marc.monot@pasteur.fr
Status: Closed


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