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#6766 : Cellular microRNA signatures in Multiple Sclerosis
Topics: Transcriptomics (Illumina)
Origin: IP
Project type: Expertise

Name of Applicant: Michel Frederique
Date of application: 14-02-2022
Unit: Cytokine Signaling
Location: Metchnikoff
Phone: 0145688638
@ Mail: frederique.michel@pasteur.fr

Project context and summary:

Multiple sclerosis is a chronic inflammatory, autoimmune and neurodegenerative disease of the central nervous system. We are looking for biomarkers testifying on the one hand, to the evolution of the disease, and on the other hand to the therapeutic activity of the treatment with interferon-beta. In this context, our project aims to determine microRNA signatures in populations of immune cells that exert a harmful activity in the disease. Several studies have shown that the expression of microRNAs is often abnormal in diseases. In addition, microRNAs are involved in the development of the immune response and in the control of the functional activity of immune cells. This project will use potent technologies such as high-throughput sequencing to expand knowledge on the variation in their expression and on their role in the pathophysiology of multiple sclerosis. Ultimately, microRNA cellular signatures may be used as prognostic biomarkers of the disease.


Related team publications:
Devi-Marulkar P, Moraes-Cabe C, Campagne P, Corre B, Meghraoui-Kheddar A, Bondet V, Llibre A, Duffy D, Maillart E, Papeix C, Pellegrini S, Michel F. Altered Immune Phenotypes and HLA-DQB1 Gene Variation in Multiple Sclerosis Patients Failing Interferon β Treatment. Front Immunol. 2021 May 25;12:628375. doi: 10.3389/fimmu.2021.628375. eCollection 2021. PMID: 34113337
Rubino E, Cruciani M, Tchitchek N, Le Tortorec A, Rolland AD, Veli Ö, Vallet L, Gaggi G, Michel F, Dejucq-Rainsford N, Pellegrini S. Human Ubiquitin-Specific Peptidase 18 Is Regulated by microRNAs via the 3’Untranslated Region, A Sequence Duplicated in Long Intergenic Non-coding RNA Genes Residing in chr22q11.21. Front Genet. 2021 Feb 3;11:627007. doi: 10.3389/fgene.2020.627007. eCollection 2020. PMID: 33633774
U. Govender, B. Corre, Y. Bourdache, S. Pellegrini and F. Michel. 2017. Type I interferon-enhanced IL-10 expression in human CD4 T cells is regulated by STAT3, STAT2, and BATF transcription factors. J. Leukoc. Biol. 101(5):1181-1190. Epub 2017 Feb 27. PMID: 28242623 DOI :10.1189/jlb.2A0416-187RR
Service Delivery
Manager: marc.monot@pasteur.fr
Status: Closed


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