Topics: Genomics (Illumina)
Origin: IP
Project type: Service
Name of Applicant: Jan Madacki
Date of application: 24-09-2021
Unit: Integrated Mycobacterial Pathogenomics
Location: Guérin 02 05
Phone: 3093
@ Mail: jan.madacki@pasteur.fr
@ PI-Mail: roland.brosch@pasteur.fr
Project context and summary: Mycobacteria have a unique form of chromosomal DNA transfer otherwise known as distributive conjugal transfer (DCT). This project aims to study the molecular factors that are responsible for the uptake of chromosomal DNA in slow growing, pathogenic mycobacteria by sequencing the genomes of putative recombinants.
Related team publications:Jan Madacki, Mickael Orgeur, Guillem Mas Fiol, Wafa Frigui, Laurence Ma, Roland Brosch. ESX-1-Independent Horizontal Gene Transfer by Mycobacterium tuberculosis Complex Strains. 2021 May 18;12(3):e00965-21. doi: 10.1128/mBio.00965-21.
Eva C Boritsch, Varun Khanna, Alexandre Pawlik, Nadine Honoré, Victor H Navas, Laurence Ma, Christiane Bouchier, Torsten Seemann, Philip Supply, Timothy P Stinear, Roland Brosch. Key experimental evidence of chromosomal DNA transfer among selected tuberculosis-causing mycobacteria. Proc Natl Acad Sci U S A . 2016 Aug 30;113(35):9876-81. doi: 10.1073/pnas.1604921113. Epub 2016 Aug 15.
Manager: laurence.ma@pasteur.frStatus: Closed
