Topics: Transcriptomics (Illumina)
Origin: IP
Project type: Service
Name of Applicant: Mathieu Picardeau
Date of application: 23-07-2020
Unit: Biology of Spirochetes
Location: BioTop
Phone: 0145688368
@ Mail: mpicard@pasteur.fr
Project context and summary: Leptospira species belong to the phylum of Spirochetes that are atypical bacteria different from many model bacteria. CsrA (or its homolog RsmA) is one of the most studied RNA-binding proteins in bacteria but its role in Spirochetes is not known. This study aims to characterize the role of CsrA in gene regulation in Leptospira. A comparative transcriptome analysis of wild-type and csrA mutant strains will allow us to identify genes and non-coding small RNAs that are specifically regulated by CrsA, providing insights into the regulatory systems in these atypical bacteria.
Related team publications:An asymmetric sheath controls flagellar supercoiling and motility in the leptospira spirochete. Gibson KH, Trajtenberg F, Wunder EA, Brady MR, San Martin F, Mechaly A, Shang Z, Liu J, Picardeau M, Ko A, Buschiazzo A, Sindelar CV. Elife. 2020 Mar 11;9:e53672. doi: 10.7554/eLife.53672.
FcpB Is a Surface Filament Protein of the Endoflagellum Required for the Motility of the Spirochete Leptospira. Wunder EA Jr, Slamti L, Suwondo DN, Gibson KH, Shang Z, Sindelar CV, Trajtenberg F, Buschiazzo A, Ko AI, Picardeau M. Front Cell Infect Microbiol. 2018 May 8;8:130. doi: 10.3389/fcimb.2018.00130.
Manager: juliana.pipoli-da-fonseca@pasteur.frStatus: Closed
