Topics: Transcriptomics (Illumina)
Origin: IP
Project type: Development
Name of Applicant: Emma BERGSTEN
Date of application: 23-06-2026
Unit: Biology and Genetics of Bacterial Cell Wall
Location: Duclaux, Rdc
Phone: 0681049691
@ Mail: emma.bergsten@pasteur.fr
@ PI-Mail: nathalie.rolhion@inserm.fr
Project context and summary: Faecalibacterium prausnitzii is a major commensal bacterium of the healthy human gut microbiota and is reduced in patients with Crohn’s disease. In this project we aim to perform RNA-seq to characterize the transcriptome of F. prausnitzii under standard culture conditions. The objective is to obtain a global overview of genes that are expressed or not expressed in this condition and to identify main active biological functions. These data will provide a basal transcriptomic description of F. prausnitzii and support future studies on its role in intestinal homeostasis and role in inflammatory bowel disease.
Related team publications:Sokol H, Pigneur B, Watterlot L, et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci U S A. 2008;105(43):16731-16736. doi:10.1073/pnas.0804812105
Danne C, de Oliveira Formiga R, Creusot L, et al. Faecalibacterium prausnitzii Induces an Anti-inflammatory Response and a Metabolic Reprogramming in Human Monocytes. Gastroenterology. 2026;170(4):704-720. doi:10.1053/j.gastro.2025.10.003
Status: New
