This project aims to investigate the genomic characteristics of Tunisian clinical strains of Ureaplasma spp. using high-throughput sequencing approaches. Ureaplasma parvum and Ureaplasma urealyticum species are important urogenital mycoplasmas associated with many reproductive and neonatal infections, and their management is increasingly challenged by the emergence of antimicrobial resistance.
45 clinical isolates collected in Tunisia will be subjected to whole-genome sequencing, followed by comprehensive bioinformatic and comparative genomic analyses. The study will focus on identifying genetic determinants of antibioresistance, characterizing genomic variability, and exploring the evolutionary dynamics of resistance mechanisms within local strains.
The sequencing and downstream analyses will contribute to improving the understanding of Ureaplasma population structure in Tunisia and will provide valuable data for surveillance, epidemiology, and future therapeutic strategies.
Furthermore, the generated genome sequences will be deposited in international public databases, thereby enriching global genomic resources and strengthening the representativeness of Ureaplasma spp.
