Project

Yersinia pseudotuberculosis is a human pathogen associated with gastrointestinal symptoms such as fever, abdominal pain, and diarrhea, frequently progressing to mesenteric adenitis. In some cases, digestive infection can be complicated by systemic disease, which predominantly affects elderly individuals or patients with underlying conditions. Population structure analyses of Y. pseudotuberculosis suggest that distinct genotypes are differentially associated with clinical outcomes, with some more frequently linked to gastrointestinal disease and others to systemic infection. The aim of this study is to identify differences in bacterial gene expression between these genotypes in order to elucidate molecular mechanisms underlying the two clinical outcomes.