Topics: Origin: Project type: Development
Name of Applicant: Lauriane Kergoat
Date of application: 25-11-2025
Unit: Mitochondrial Biology
Location: Phone: @ Mail: lauriane.kergoat@pasteur.fr
@ PI-Mail: timothy.wai@pasteur.fr
Project context and summary: ORF9b is a protein encoded by the SARS-CoV-2 virus that physically interacts with TOMM70 on the surface of mitochondria. How this protein remodels mitochondrial function during infection is unclear, as its potential impact on pathogenesis. To this end, we will conduct infection experiments on hamsters using SARS-CoV-2 and genetically engineered viral variants lacking functional ORF9b to conduct a comprehensive study including transcriptomics, proteomics, and histology.
Related team publications:Saunders, N., Monel, B., Cayet, N., Archetti, L., Moreno, H., Jeanne, A., Marguier, A., Buchrieser, J., Wai, T., Schwartz, O., et al. (2024). Dynamic label-free analysis of SARS-CoV-2 infection reveals virus-induced subcellular remodeling. Nat. Commun. 15, 4996. https://doi.org/10.1038/s41467-024-49260-7
Status: New
