Topics: Genomics (Long Read)
Origin: Academic
Project type: Expertise
Name of Applicant: Pamela Schnupf
Date of application: 24-09-2025
Unit: Ultrapole
Location: Francois Jacob (26), Ground floor, Mezzanine
Phone: 0698399692
@ Mail: pamela.schnupf@inserm.fr
Project context and summary: The microbiota plays an integral role in both health of disease. While most studies focus on the most abundant bacterial species within the gut microbiome, low frequency commensals can have an outsized effect on the host.
In order to investigate the low abundant microbiome, we aim to use nanopore adaptive sampling to obtain genetic information on a group of commensals that proliferate in the ileum and are involved in host immune activation.
Related team publications:Segmented filamentous bacteria, Th17 inducers and helpers in a hostile world. Schnupf P, Gaboriau-Routhiau V, Sansonetti PJ, Cerf-Bensussan N. Curr Opin Microbiol. 2017 Feb;35:100-109. doi: 10.1016/j.mib.2017.03.004.
Intracellular offspring released from SFB filaments are flagellated. Nkamba I, Mulet C, Dubey GP, Gorgette O, Couesnon A, Salles A, Moya-Nilges M, Jung V, Gaboriau-Routhiau V, Guerrera IC, Shima T, Umesaki Y, Nigro G, Krijnse-Locker J, Bérard M, Cerf-Bensussan N, Sansonetti PJ, Schnupf P. Nat Microbiol. 2020 Jan;5(1):34-39. doi: 10.1038/s41564-019-0608-1.
Manager: chloe.baum@pasteur.frStatus: Kick-off meeting
