Sarcoidosis (SARC) is a multisystemic granulomatous disease with unknown aetiology, sharing clinical similarities with tuberculosis (TB). We hypothesized that maladaptive innate immune training drives SARC pathogenesis.
To test this hypothesis, we established a prospective clinical study (NCT05916638) to compare 14 SARC cases at diagnosis to 20 TB patients, and 23 healthy controls (HC). We performed an integrated immunological analysis including plasma proteomic profiling, whole blood spectral cytometry, genome wide transcriptomic and epigenetic profiling of isolated blood monocytes.
Our findings provide evidence that distinct epigenetic monocyte signature differentiate SARC from TB while they share similar proteomic and phenotypic profiles. Ongoing work will integrate functional assays to further elucidate granulomatous disease mechanisms, and identify potential therapeutic targets.
