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#19954 : Postprandial Metabolic Alterations and Their Role in the Pathogenesis of MASLD
Topics: Single Cells
Origin: Academic
Project type: Expertise

Name of Applicant: Cosmin Voican
Date of application: 09-07-2025
Unit: Other
Location: UFR de Pharmacie, Bât. Henri Moissan (4ème étage), 17 avenue des Sciences, 91400 ORSAY
Phone: 0625130603
@ Mail: cosmin.voican@aphp.fr
@ PI-Mail: cassard.doulcier@universite-paris-saclay.fr

Project context and summary:

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease in Western societies, closely associated with obesity, type 2 diabetes, cardiovascular diseases, and metabolic syndrome. It has emerged as the fastest growing cause of hepatocellular carcinoma and a leading indication for liver transplantation1. Despite its widespread prevalence and clinical impact, the mechanisms underlying MASLD progression remain poorly understood.
A recent study has reported that postprandial plasma lipidomics reveal specific alterations in hepatic-derived diacylglycerols in both MASLD patients and mouse models, highlighting the importance of dynamic metabolic responses after meals.
This project takes an integrative approach by combining clinical serum/plasma samples from MASLD patients at defined postprandial time points with mouse models fed a Western diet. Using highly targeted lipidomics, we identified a postprandial increase in diacylglycerols in MASLD mouse plasma.
Through untargeted metabolomics, lipidomics, and snRNA-seq, we aim to map the dynamic postprandial metabolic landscape in MASLD.
By uncovering cell-specific responses to postprandial metabolic stress, our research aims to identify novel therapeutic targets and provide mechanistic insights into MASLD progression.


Related team publications:
Miura Y, Voican C, Sakai Y, Nishikawa M, Leclerc E. A computational model of the crosstalk between hepatocyte fatty acid metabolism and oxidative stress highlights the key 5 enzymes, metabolites, and detoxification pathways in the context of MASLD. Toxicol Appl Pharmacol 2025;495:117185
Sanchez D, Lebrun A, Somda S, Zaidan M, Tranchart H, Lamouri K, Njike-Nakseu M, Lainas P, Gaillard M, Balian A, Dagher I, Perlemuter G, Naveau S, Voican CS. Impact of sleeve gastrectomy on renal function in patients with morbid obesity: a one year prospective cohort study. Langenbecks Arch Surg 2022; 407:3323-3332.
Petroff D, Blank V, Shalimar, Newsome P, Voican CS, Thiele M, de Lédinghen V, Baumeler S, Chan WK, Perlemuter G, Naveau S, Cardoso AC, Aggarwal S, Sasso M, Lupsor-Platon M, Mueller S, Semela D, Wong GL, Wong VW, Villela-Nogueira C, Wiegand J, Karlas T. Individual Patient Data Meta-Analysis (IPDMA) on Controlled Attenuation Parameter (CAP) Technology in Obese Patients (XL-Probe). Lancet Gastroenterol Hepatol 2021;6(3):185-198.
Service Delivery
Manager: marc.monot@pasteur.fr
Status: Kick-off meeting


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