Tissue regeneration is widespread among animal species. Following cell death, regeneration requires compensatory proliferation of the surviving cells to replace lost cells. I use the Drosophila wing imaginal disc in order to address the spatio-temporal regulation of regeneration following cell death with single cell resolution.I showed that following cell death in clones, there is a transient growth reduction and delay in developmental delay that are JNK- and dilp8- dependent. This delay is necessary for size compensation in adult tissues. We now wish to better characterize the molecular signals involved in the dilp8 reponse thanks to RNA sequancing.
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