Juvenile dermatomyositis (JDM) is a rare pediatric inflammatory disease characterized by a Type I interferon (IFN-I) signature that correlates with clinical activity. Mechanisms leading to the dysregulation of IFN-I remain largely unknown. In collaboration with Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques – CNRS (Dr. Mathieu Rodero) and clinicians from French hospitals, the aim of this project is to use genomics approaches to better understand cellular and molecular mechanisms involved in JDM pathophysiology.
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