Topics: Single Cells (GEX/ATAC/ADT/Multiome…)
Origin: IP
Project type: Expertise
Name of Applicant: Emma Beaumont
Date of application: 24-11-2023
Unit: HIV, Inflammation and Persistence
Location: François Jacob, 3rd floor, 26-03-05a
Phone: +33 153551531
@ Mail: emma.beaumont@pasteur.fr
@ PI-Mail: michaela.muller-trutwin@pasteur.fr
Project context and summary: Natural Killer cells are known to play a crucial role in protective immunity against viral infection and cancer. The inflammatory state, induced by the metabolism challenge of obesity, strongly interferes with the function of immune cells and obesity has been associated with NK cell dysfunction.
We have shown that they play an important role in the control of SIV/HIV replication in secondary lymphoid organs. During the last years, obesity has become a major global public health issue.Recent studies have shown that the prevalence of obesity in people living with HIV (PLWH) has increased over the last two decades, partly due to the aging of the population of people living with HIV, improved access to treatments and in some cases following the introduction of specific antiretrovirals.
In this project, we propose to investigate the consequences of obesity on the NK cells.
Related team publications:Huot, Nicolas, Philippe Rascle, Caroline Petitdemange, Vanessa Contreras, Christina M. Stürzel, Eduard Baquero, Justin L. Harper, et al. 2021. “SIV-Induced Terminally Differentiated Adaptive NK Cells in Lymph Nodes Associated with Enhanced MHC-E Restricted Activity.” Nature Communications 12 (1): 1282. https://doi.org/10.1038/s41467-021-21402-1.
Gondois-Rey, Françoise, Antoine Chéret, Samuel Granjeaud, Françoise Mallet, Ghislain Bidaut, Camille Lécuroux, Mickaël Ploquin, et al. 2017. “NKG2C+ Memory-like NK Cells Contribute to the Control of HIV Viremia during Primary Infection: Optiprim-ANRS 147.” Clinical & Translational Immunology 6 (7): e150. https://doi.org/10.1038/cti.2017.22.
Gondois-Rey, Françoise, Antoine Chéret, Françoise Mallet, Ghislain Bidaut, Samuel Granjeaud, Camille Lécuroux, Mickaël Ploquin, et al. 2017. “A Mature NK Profile at the Time of HIV Primary Infection Is Associated with an Early Response to cART.” Frontiers in Immunology 8: 54. https://doi.org/10.3389/fimmu.2017.00054.
Manager: chloe.baum@pasteur.frStatus: Sequencing
