Topics: Metagenomics (Shotgun)
Origin: Academic
Project type: Expertise
Name of Applicant: Roberto Motterlini
Date of application: 10-11-2023
Unit: Other
Location: Faculty of Health University Paris Est Créteil 94000 Créteil
Phone: 0149813637
@ Mail: roberto.motterlini@inserm.fr
Project context and summary: Alterations in the gut microbiota composition and function (dysbiosis) contribute to obesity and associated morbidities. Based on recent findings by our group that exogenous carbon monoxide (CO) reduces weight gain and metabolic derangement in obese mice, we hypothesize that CO affords these salutary effects by shaping the microbiota towards a healthy phenotype during obesity. To explore this idea, we will examine whether exogenous or endogenous CO alters the microbiota composition and modulates its function in obesity during aging. It is hypothesized that CO will favor selection of bacterial species that produce microbial signals with beneficial metabolic effects on the host, thus counteracting the high fat diet (HFD)-induced obesity and associated diseases.
Related team publications:Mohan S, Barel LA, Benrahla D, Mao Q, Kitagishi H, Rivard M, Motterlini R* and Foresti R*. Development of carbon monoxide-releasing molecules conjugated to polysaccharides (Glyco-CORMs) for delivering CO during obesity. Pharmacol. Res., 191:106770, 2023.
Amorim MR, Foresti R, Benrahla DE, Motterlini R*, Branco LGS. CORM-401, an orally active carbon monoxide-releasing molecule, increases body temperature by activating non-shivering thermogenesis in rats. Temperature 9:310-317, 2022
Braud L, Pini M, Muchova L, Manin S, Kitagishi H, Sawaki D, Czibik G, Derumeaux G, Foresti R* and Motterlini R*. Carbon monoxide-induced metabolic switch in adipocytes improves insulin resistance in obese mice. JCI Insight 3:e123485, 2018
Manager: azimdine.habib@pasteur.frStatus: Closed
