Glioblastoma multiforme (GBM) is the most aggressive and frequent brain cancer with a very poor prognosis. It is a highly invasive and infiltrating tumour with glioblastoma cells often invading the normal brain parenchyma. GBM is resistant to any current available treatments and despite more than 10 years of extensive research, virtually all patients undergo relapse. This tumour is characterised by an increase in the density and stiffness of the extracellular matrix which can promote cancer growth and invasion and provide resistance to the penetration of therapeutic drugs. The intermediate filament vimentin is considered one of the most common markers of glioblastoma malignancy and vimentin expression is often associated with an increased invasive potential of cancer cells. Within a multidisciplinary approach, combining biophysical techniques with transcriptomic analysis, we investigate the contribution of vimentin in the control of gene expression of glioblastoma cells
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