Topics: Genomics (Illumina)
Origin: IP
Project type: Expertise
Name of Applicant: MONTAGUTELLI Xavier
Date of application: 26-05-2023
Unit: Mouse Functional Genetics
Location: Metchnikoff S1 23
Phone: 8955
@ Mail: xavier.montagutelli@pasteur.fr
Project context and summary: While SARS-CoV-2 variants of the Omicron lineage have proven much less pathogenic to mice than previous variants, even to mice transgenic for the human ACE2 receptor, we have identified mouse pedigrees in which infection with Omicron results in very high brain viral loads. The aim of the project is ton contribute to the characterization of this novel genetic susceptibility variant.
Related team publications:1. Montagutelli X, Prot M, Levillayer L, Salazar EB, Jouvion G, Conquet L, Beretta M, Donati F, Albert M, Gambaro F, Behillil S, Enouf V, Rousset D, Mouquet H, Jaubert J, Rey F, van der Werf S, Simon-Loriere E. Variants with the N501Y mutation extend SARS-CoV-2 host range to mice, with contact transmission. bioRxiv. 2021:2021.03.18.436013. doi: 10.1101/2021.03.18.436013.
1. Montagutelli X, Prot M, Jouvion G, Levillayer L, Conquet L, Reyes-Gomez E, Donati F, Albert M, van der Werf S, Jaubert J, Simon-Lorière E. A mouse-adapted SARS-CoV-2 strain replicating in standard laboratory mice. bioRxiv. 2021:2021.07.10.451880. doi: 10.1101/2021.07.10.451880.
Manager: laurence.ma@pasteur.frStatus: Closed
