Project

Go Back to Project List
#16443 : Micromod
Topics: Metagenomics (16s)
Origin: IP
Project type: Expertise

Name of Applicant: Lulla Opatowski
Date of application: 20-03-2023
Unit: Pharmacopepidemiology and Infectious Diseases
Location: Laveran
Phone: 0145688301
@ Mail: lulla.opatowski@pasteur.fr

Project context and summary:

The human microbiota plays major roles in host infections. It can protect the host against infection, or on the
contrary facilitate invasion by pathogens. In parallel to the increasing access to microbiota data, many efforts
have been made in the past ten years to develop realistic ecological models of pathogens growth within
humans.
This project aims at encompassing the within-host and the between-host scales in order to study their interplay
in the processes of acquisition and transmission of pathogenic bacteria, with a focus on antibiotic-resistant
bacteria. Our objectives are to: (1) characterize microbial communities within the host and identify microbial
species who can play a role in the infection process, (2) to develop models of the within-host dynamics of
microbial species accounting for ecological interactions between microorganisms , and finally (3) encompass
the within- and between-host dynamics, by considering inter-individual heterogeneities in a single model
describing the impact of between-humans contacts on the diffusion of a pathogen in the population. Our
project will rely on epidemiological data and samples collected in several epidemiological cohorts, including
nasal samples from the follow up of patients and health care workers over 4 months in a long term care facility
(i-Bird study). We will study the specific case of colonisation or infection by S. aureus in the nasal microbiota.


Related team publications:
Labarthe S. et al. ESAIM Proc 67:261-84 (2020) doi.org/10.1051/proc/202067015
Gao X, Huynh B-T, Guillemot D, Glaser P and Opatowski L. Inference of Significant Microbial Interactions From Longitudinal Metagenomics Data. Front. Microbiol., 16 October 2018 https://doi.org/10.3389/fmicb.2018.02319
Obadia T, Silhol R, Opatowski L, Temime L, Legrand J, Thiébaut AC, Herrmann JL, Fleury É, Guillemot D, Boëlle PY; I-Bird Study Group. Detailed contact data and the dissemination of Staphylococcus aureus in hospitals. PLoS Computational Biology. 2015 Mar 19;11(3):e1004170. doi: 10.1371/journal.pcbi.1004170.
Service Delivery
Manager: georges.haustant@pasteur.fr
Status: Libraries


Go Back to Project List