Listeria monocytogenes is a foodborne pathogen responsible for severe infections, including infection of the brain called neurolisteriosis.
Listeria monocytogenes is known to infect and alter immune cells in the different organs it infects (liver, spleen, intestine). In the brain, immune cells are mostly comprised of resident macrophages called microglia. Their role during Listeria brain infection is however poorly understood.
In this project, we will investigate the transcriptome of immune cells in the brain of mice infected with Listeria monocytogenes to address the dynamics and changes in the immune landscape in the brain. We will also investigate the changes in immune cells populations after resolution of the infection to assess long-term changes.
