Institut Pasteur
Biomics
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Deciphering the role of choroid plexus activation on long term cognition

Status: Libraries

Project ID: B21907

Owner: Samir Ali-Moussa

Unit: Department of Immunology

Experiment type: To be determined

Location: 67-02-06

Description

Preliminary data shows that early-life MC activation drives choroid plexus (CP) activation and long term cognitive impairment. To investigate the role of CP activation, we have developed a model in which mast cells are activated but the subsequent response from the CP is inhibited. To investigate the molecular effects of this phenomena, we will focus on the hippocampus, the center for memory formation.

Submitted: 2026-09-11 09:06 · Last updated: 2026-09-11 09:06