Status: Awaiting samples
ORF9b is a protein encoded by the SARS-CoV-2 virus that physically interacts with TOMM70 on the surface of mitochondria. How this protein remodels mitochondrial function during infection is unclear, as its potential impact on pathogenesis. To this end, we will conduct infection experiments on hamsters using SARS-CoV-2 and genetically engineered viral variants lacking functional ORF9b to conduct a comprehensive study including transcriptomics, proteomics, and histology.
Submitted: 2025-11-25 14:26 · Last updated: 2026-08-13 14:00