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Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease in Western societies, closely associated with obesity, type 2 diabetes, cardiovascular diseases, and metabolic syndrome. It has emerged as the fastest growing cause of hepatocellular carcinoma and a leading indication for liver transplantation1. Despite its widespread prevalence and clinical impact, the mechanisms underlying MASLD progression remain poorly understood. A recent study has reported that postprandial plasma lipidomics reveal specific alterations in hepatic-derived diacylglycerols in both MASLD patients and mouse models, highlighting the importance of dynamic metabolic responses after meals. This project takes an integrative approach by combining clinical serum/plasma samples from MASLD patients at defined postprandial time points with mouse models fed a Western diet. Using highly targeted lipidomics, we identified a postprandial increase in diacylglycerols in MASLD mouse plasma. Through untargeted metabolomics, lipidomics, and snRNA-seq, we aim to map the dynamic postprandial metabolic landscape in MASLD. By uncovering cell-specific responses to postprandial metabolic stress, our research aims to identify novel therapeutic targets and provide mechanistic insights into MASLD progression.
Submitted: 2025-07-09 14:15 · Last updated: 2025-08-06 07:34