Assessing the impact of the secreted Leishmania kinase, casein kinase 1.2, on the trancriptome of infected macrophages.

Status: Awaiting samples

Project ID: B18090

Owner: Sharvani Shintre

Unit: Molecular Parasitology and Signaling

Experiment type: To be determined

Location: Calmette, gauche-62-02-08

Description

Mouse bone marrow dervied macrophages were infected with Leishmania donovani amastigotes. It is known that L. donovani secretes a kinase L-CK1.2 into the macrophage during infection. To study the specific impact of L-CK1.2 on the host, we inhibit the kinase and then look at the changes on the host transcriptome.

Submitted: 2024-03-13 10:18 · Last updated: 2024-06-06 08:36