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#3790 : RNA expression profile of Tregs imprinted during weaning
Topics:
Origin:
Project type: Development

Name of Applicant: Gerard Eberl
Date of application: 17-02-2020
Unit: Microenvironment and Immunity
Location: Metchnikoff RdC
Phone: 9446
@ Mail: gerard.eberl@pasteur.fr

Project context and summary:

The weaning reaction is necessary to prevent pathological imprinting into adulthood, i.e. increased susceptibility to inflammatory pathologies (Al Nabhani, Immunity 2019). Regulatory T cells (Tregs) are required during the weaning reaction and carry protective imprinting. In this project, we assess the transcriptome profile of Tregs at different time points during and after weaning, in mice that carry protective or pathological imprinting.


Related team publications:
Z. Al Nabhani, S. Dulauroy, R. Marques, C. Cousu, S. Al Bounny, F. Dejardin, T. Sparwasser, M. Bérard, N. Cerf-Bensussan and G. Eberl. 2019. A weaning reaction to microbiota is required for resistance to immunopathologies in the adult. Immunity, 50:1276-1288.
Z. Al Nabhani, S. Dulauroy, E. Lecuyer, B. Polomack, M. Bérard and G. Eberl. 2019. Excess calorie intake early in life increases susceptibility to colitis in the adult. Nat. Metabol., 1:1101-1109.
Z. Al Nabhani and G. Eberl. 2020. Imprinting of the immune system by the microbiota early in life. Mucosal Immunol., in press.
Service Delivery
Status: Closed


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