Project

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#7406 : Post-natal establishment of the immune niche at the choroid plexuses
Topics: Single Cells
Origin: IP
Project type: Service

Name of Applicant: Laetitia Travier
Date of application: 01-07-2022
Unit: Other
Location: Metchnikoff – 2nd floor – 2010
Phone: 33 1 86 46 73 92
@ Mail: laetitia.travier@pasteur.fr
@ PI-Mail: aleksandra.deczkowska@pasteur.fr

Project context and summary:

Aging-associated dementia and neurodegenerative diseases, such as Alzheimer’s disease, become an overwhelming societal problem, but despite tremendous efforts and means put into the development of therapies to fight them, we are still missing a cure. It is now appreciated that immune cells and pathways shape brain function in, however understanding of the mechanisms of this brain-immune cross talk is in its infancy. One specific site of such communication is choroid plexus (CP), an immunologically active single layer epithelium, which separates fenestrated blood vessels form the cerebrospinal fluid (CSF) in the brain ventricles. We aim to explore how immune cell activity at the choroid plexus (CP) shapes brain function in health and in aging. More precisely, in a similar manner than it has been described at the gut level, we hypothesize that post-natal establishment of the immune-CP crosstalk, in response to age and microbiome development, condition brain homeostasis and that perturbations of this process early in age may lead to alterations in the brain activity later in adult and in aging. To validate our hypothesis, we plan to analyze using a single cell transcriptomic approach the genes expressed by isolated immune cells from CP and those isolated from the whole CP, according to age and microbiome, and to compare the results of these two analyses to identify specific immune-CP interactions that may vary along the post-natal development.


Related team publications:
Service Delivery
Manager: marc.monot@pasteur.fr
Status: Closed


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